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• Vol.43 No.3
• CLINICA NEUROL, 43: 126−129, 2003
• Vol.43 No.3 contents

Brief Clinical Note

A case of brain infarction with nephrotic syndrome

Masaki Naganuma, M.D.¹⁾, Rhyoko Sugimoto, M.D.¹⁾, Yoichiro Hashimoto, M.D.¹⁾, Yutaka Matsuura, M.D.²⁾, Tadashi Terasaki, M.D.²⁾ and Uchino Makoto, M.D.³⁾

Department of ¹⁾Neurology and ²⁾Strokology, Kumamoto city Hospital, ³⁾Department of Neurology, Kumamoto University School of Medicine

A 47-year-old man lost his consciousness and brought to our hospital by ambulance. On admission, he had aphasia and upper right limb paresis. Diffusion weighted MR image of the brain on admission showed multiple high intensity areas in the left middle cerebral artery (MCA) territory. Brain angiography performed on the 2^nd hospital day revealed the left MCA severe stenosis. We started intravenous antithrombotic therapy on the 1^st day. The left carotid angiography on 12^nd day demonstrated that the left MCA stenosis was improved. He had medical history of hypertension, diabetes mellitus and gout. But he had only slight atherosclerosis, and had no arrythmia and patent foramen ovale. Blood chemistry test showed marked hypoproteinemia and hyperlipidemia, and urine examination showed proteinuria. He was diagnosed as nephrotic syndrome for the first time. Nephrotic syndrome brought hypercoagulability, so we suspected that nephrotic syndrome concerned with brain infarction.

(CLINICA NEUROL, 43: 126−129, 2003)
key words: brain infarction, nephrotic syndrome, platelet aggregation, vWF, middle cerebral artery stenosis

(Received: 11-Nov-02)