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• Vol.56 No.10
• CLINICA NEUROL, 56: 672−677, 2016
• Vol.56 No.10 contents

Case Report

A case of chronic inflammatory demyelinating polyradiculoneuropathy after treatment with pegylated interferon α-2a in a patient with chronic hepatitis B virus infection

Hiroyuki Naito, M.D.¹⁾, Ikuko Takeda, M.D., Ph.D.¹⁾, Akiko Segawa, M.D.¹⁾, Masataka Tsuge, M.D., Ph.D.²⁾, Hirofumi Maruyama, M.D., Ph.D.¹⁾ and Masayasu Matsumoto, M.D., Ph.D.¹⁾

¹⁾Department of Neurology, Hiroshima University Hospital
²⁾Department of Gastroenterology and Metabolism, Hiroshima University Hospital

We report the case of a 42-year-old man with chronic hepatitis B virus infection who developed weakness and paresthesia in the extremities 2 months after administration of pegylated interferon (Peg-IFN)α-2a. Nerve conduction studies conducted 6 months after onset showed abnormal temporal dispersions in both tibial nerves. We diagnosed chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) resulting from treatment with Peg-IFNα-2a. Neurological symptoms were prolonged despite suspension of the treatment. Subsequent treatment with intravenous immunoglobulin improved both clinical symptoms and temporal dispersion. IFNα-induced CIDP is rare, but can reportedly progress even after interruption of IFN-α without immunotherapy. Patients presenting with polyneuropathy after initiation of IFN-α thus require close attention.
Full Text of this Article in Japanese PDF (552K)

(CLINICA NEUROL, 56: 672−677, 2016)
key words: chronic inflammatory demyelinating polyradiculoneuropathy, pegylated interferon α-2a, chronic hepatitis B virus infection, intravenous immunoglobulin

(Received: 16-Mar-16)