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- Vol.47 No.9
- CLINICA NEUROL, 47: 581－584, 2007
- Vol.47 No.9 contents
Case Report
An autopsy case of atypical type of Alzheimer's disease clinically diagnosed as corticobasal degeneration
Miho Osako, M.D.1), Yoko Mochizuki, M.D.2)3), Yumiko Kugio, M.D.1), Toshio Mizutani, M.D.2) and Hideaki Hayashi, M.D.1)
1)Department of Neurology, Tokyo Metropolitan Neurological Hospital
2)Department of Pathology, Tokyo Metropolitan Neurological Hospital
3)Department of Internal Medicine, Tokyo Metropolitan Kita Medical and Rehabilitation Center
A 60-year-old, right-handed man developed gait disturbance. He also had difficulty in dressing and demonstrated depressive status, but did not have memory impairment. He was diagnosed as having corticobasal degeneration (CBD) because of right cortical atrophy and contralateral movement disorder. He died at the age of 69. The pathological diagnosis was not CBD but Alzheimer's disease. The brain showed severe atrophy, especially in the right superior parietal lobe and postcentral gyrus. The cortical lesion was most marked in the right parietal lobe within the neocortex, and was more severe than that in the limbic area. Clinically this patient was highly suspected to have CBD. This case, however, is categorized into atypical Alzheimer's disease with a focal cortical syndrome.
(CLINICA NEUROL, 47: 581－584, 2007)
key words: Alzheimer's disease, corticobasal degeneration, parietal lobe, asymmetrical atrophy, neuropathology
(Received: 4-Dec-06)
