＜シンポジウム（2）―1―1＞重症筋無力症：臨床の問題点とその解決法
MG患者による主観的QOLスケールの必要性：MG-QOL 15日本語版の作成
増田 眞之1）, 槍沢 公明2）, 鈴木 重明3）, 長根 百合子2）,伊藤 傑1）, 蒲澤 千昌4）, 鈴木 靖士5）, 清水 優子4）, 内海 裕也1）, 藤原 一男6）, 内山 真一郎4）, 鈴木 則宏3）
1）東京医科大学病院神経内科〔〒160―0023 東京都新宿区西新宿6―7―1〕
2）総合花巻病院神経内科
3）慶応義塾大学神経内科
4）東京女子医大神経内科
5）仙台医療センター神経内科
6）東北大学神経内科
We produced a Japanese translation of the 15-item myasthenia gravis (MG)-specific quality of life (QOL) scale (MG-QOL15), assessed its reliability and validity, and examined clinical factors affecting the self-perceived QOL in MG. Consecutive 327 patients with MG seen at six neurological centers were evaluated. All patients completed an MG-QOL15 Japanese version (MG-QOL15-J), the Beck Depression Inventory-Second Edition (BDI-II), and a generic health-related QOL questionnaire, the SF-36. Disease severity was determined according to the MG Foundation of America (MGFA) quantitative MG score and the MG composite. The MG-QOL15-J exhibited adequate internal reliability, test-retest repeatability, and concurrent validity with SF-36, disease severity, and known-patient groups categorized by MGFA postintervention status. Multivariate analysis revealed severity, dose of oral corticosteroids, and BDI-II as independent factors negatively affecting QOL. The MG-QOL15-J is anticipated to be a valuable clinical measure of QOL in Japanese patients with MG.
Full Text of this Article in Japanese PDF (309K)
(臨床神経, 52：1043−1046, 2012)
key words：横断的研究，生活クオリティー，重症筋無力症，質問票，妥当性検証
（受付日：2012年5月23日）
