臨床神経学

第51回日本神経学会総会

<シンポジウム18―3>辺縁系をめぐって
辺縁系と自律神経系

上山 敬司1), 仙波 恵美子2)

1)和歌山県立医科大学医学部解剖学第一講座〔〒641―0012 和歌山市紀三井寺811―1〕
2)同 第二解剖

The viral transneuronal labeling method using pseudorabies virus (PRV) is an ideal technique for identifying the central sites that regulate the sympathetic nervous system. Regions were identified in limbic system such as extended amygdaloid complex, lateral septum, infralimbic, insular, ventromedial temporal cortical regions, as well as in several hypothalamic and brain stem nuclei. Emotional stress causes rapid and transient expression of immediate early genes (IEGs) such as c-Fos in the brain, and the monitoring of IEGs has enabled the visualization of the neurocircuitry of stress. By a comparison of the data from the separate PRV and c-Fos neuroanatomical labeling techniques, the central sites which regulate emotional stress-induced sympathoadrenal activation can be deduced. Estrogen receptors are expressed in the brain, where estrogen modulates central nervous function and autonomic nervous function. Estrogen attenuated the stress-induced c-Fos expression in medial amygdaloid nucleus, paraventricular hypothalamic nucleus; these same regions contain central sympathetic neurons and neurons with immunoreactive estrogen receptors.
Full Text of this Article in Japanese PDF (369K)

(臨床神経, 50:1003−1006, 2010)
key words:ウイルストレーサー法,c-Fos発現,扁桃体内側核,エストロゲン

(受付日:2010年5月22日)