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  会員専用

• ホーム
• 48巻11号
• 臨床神経, 48：981−983, 2008
• 48巻11号目次

第49回日本神経学会総会

＜シンポジウム8-2＞パーキンソン病の臨床，基礎の最前線
パーキンソン病の病理：レビー小体は悪玉か善玉か？

若林　孝一

弘前大学大学院医学研究科脳神経病理学講座〔〒036-8562　青森県弘前市在府町5〕

The histological hallmark of Parkinson's disease (PD) is the presence of fibrillar aggregates called Lewy bodies (LBs). LB formation has been considered to be a marker for neuronal degeneration, because neuronal loss is found in the predilection sites for LBs. To date, more than 70 molecules have been identified in LBs, in which α-synuclein is a major constituent of LB fibrils. α-Synuclein immunohistochemistry reveals that diffuse cytoplasmic staining develops into pale bodies via compaction, and that LBs arise from the peripheral portion of pale bodies. Abnormal accumulation of α-synuclein (diffuse cytoplasmic staining, pale bodies and LBs) is found in 10% of pigmented neurons in the substantia nigra and more than 50% of those in the locus ceruleus in PD. Recent studies have suggested that oligomers and protofibrils of α-synuclein are cytotoxic, and that pale bodies and LBs may represent a cytoprotective mechanism in PD.
Full Text of this Article in Japanese PDF (187K)

(臨床神経, 48：981−983, 2008)
key words：αシヌクレイン, レビー小体, パーキンソン病, 黒質

（受付日：2008年5月17日）