臨床神経学

第49回日本神経学会総会

<シンポジウム4-3>多発性硬化症の病態と治療:臨床と基礎の最前線
治療法の開発をめざして「臨床からの展望」

新野 正明

北海道大学病院神経内科〔〒060-8648 札幌市北区北14条西5丁目〕

Immunomodulatory drugs such as interferon beta (IFN-β) have modestly effective in relapsing remitting multiple sclerosis (RRMS). However, all current therapies are partially effective. The cause of MS and the determinants of heterogeneity in the clinical phenotype of MS remain largely unknown and new therapeutic approaches in MS are emerging. Even now, "bench to bed" is the only approach to find new therapies. However, we need to take part in exploring new therapies with the approach of "bench to bed and back". In the near future, studies on susceptibility genes and pharmacogenetics will provide invaluable information concerning new drugs for the treatment of MS and better therapeutic regimens for MS patients.
Full Text of this Article in Japanese PDF (162K)

(臨床神経, 48:935−936, 2008)
key words:多発性硬化症, 治療, 臨床試験, テーラーメード医療

(受付日:2008年5月16日)