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  会員専用

• ホーム
• 47巻11号
• 臨床神経, 47：790−794, 2007
• 47巻11号目次

第48回日本神経学会総会

＜教育講演7＞
ALSの原因病態と治療展望

阿部　康二

岡山大学大学院医歯薬学総合研究科神経病態内科学〔〒700-8558　岡山市鹿田町2-5-1〕

After gene mutations of SOD1 were found in familial amyotrophic lateral sclerosis (ALS) in 1993, many studies have elucidated pathogenesis of this progressive motor neuron disease. Among them, oxidative stress, impaired axonal transport, imbalance of survival & death signals, organellic stress (for mitochondria, endoplasmic reticulum and proteasome) are the most important with linking each other through energy failure within the motor neuron. New therapeutic approaches have also been tried, such as free radical scavenger edaravone, a continuous intra-thecal injection of neurotrophic factor IGF-1, and methylcobalamine as well as gene therapy with GDNF and regenerative therapy with stem cell activation and stem cell transplantation.

(臨床神経, 47：790−794, 2007)
key words：ALS, 原因病態, 治療展望, 再生医療, 遺伝子治療

（受付日：2007年5月16日）