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• Vol.64 No.3
• CLINICA NEUROL, 64: 157−162, 2024
• Vol.64 No.3 contents

Original Article

Altered antibody titers in patients with neuromuscular diseases after high-dose intravenous immunoglobulin therapy

Wataru Shiraishi, M.D., Ph.D. ¹⁾²⁾, Yukiko Inamori, M.D. ¹⁾, Ayano Matsuyoshi, M.D. ¹⁾ and Tetsuya Hashimoto, M.D., Ph.D. ¹⁾³⁾

¹⁾Department of Neurology, Kokura Memorial Hospital
²⁾Shiraishi Internal Medicine Clinic
³⁾Department of Comprehensive Strokology, Fujita Health University School of Medicine

We investigated the changes in antibody titers after intravenous immunoglobulin (IVIg) administration in patients with neuromuscular diseases. Among patients who received IVIg from April 1, 2020, to August 31, 2022, we retrospectively evaluated 15 patients with antibody measurements before and after IVIg administration for any rise in the following antibody levels and examined the data for subsequent changes of false positive results to negative ones. The levels of anti SS-A, anti-thyroglobulin, anti-thyroid peroxidase, anti-glutamic acid decarboxylase, HBs, and HBc antibodies transiently increased after IVIg administration and showed false-positive results. However, levels of rheumatoid factor and anti-nuclear and antineutrophil cytoplasmic antibodies were not elevated. The false-positive results became negative after 3 months. Here, we report on the changes in antibody levels before and after IVIg administration and note that levels of hepatitis B virus-related antibodies and various autoantibodies transiently rise after IVIg administration.
Full Text of this Article in Japanese PDF (1224K)

(CLINICA NEUROL, 64: 157−162, 2024)
key words: autoantibody, false positive, hepatitis B virus, immunotherapy, intravenous immunoglobulin

(Received: 14-Jun-23)