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• Vol.64 No.1
• CLINICA NEUROL, 64: 23−27, 2024
• Vol.64 No.1 contents

Case Report

Two cases of cerebral amyloid angiopathy in which white matter lesions appearing after brain biopsy got improvement without immunotherapy

Kohei Asano, M.D.^1）2）, Sachiko Hosoyama, M.D., Ph.D.^2） and Yuko Takeuchi, M.D., Ph.D.^2）3）

¹⁾Department of Neurology, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital
²⁾Department of Neurology, Nagoya Ekisaikai Hospital³⁾Department of Neurology, Masuko Memorial Hospital

The first case was a 75-year-old woman with intermittent sensory impairment of the left hand. FLAIR of the head MRI revealed hyperintensity along the pia mater in the right parieto-temporal lobe with few microbleeds. Our second case was a 78-year-old man who presented with motor aphasia. His MRI showed swollen cortex on FLAIR and cortical hemosiderosis on T₂^＊ weighted imaging of the right cerebral hemisphere. Pathological findings indicated the first case as cerebral amyloid angiopathy (CAA)-related inflammation and the second case as CAA. Additionally, after brain biopsy, widespread white matter lesions were detected in the area surrounding the biopsy site. However, both patients showed improvement without immunotherapy. Therefore, it is important to consider whether immunotherapy is required when white matter lesions appear in the area surrounding the biopsy site.
Full Text of this Article in Japanese PDF (1831K)

(CLINICA NEUROL, 64: 23−27, 2024)
key words: cerebral amyloid angiopathy, cerebral amyloid angiopathy-related leukoencephalopathy, cerebral amyloid angiopathy-related inflammation, brain biopsy

(Received: 12-May-23)