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• Vol.63 No.8
• CLINICA NEUROL, 63: 518−522, 2023
• Vol.63 No.8 contents

Case Report

A case of anti-myelin oligodendrocyte glycoprotein antibody-positive multiphasic disseminated encephalomyelitis showing significant recovery after immunoadsorption plasmapheresis

Shoji Ogawa, M.D.¹⁾, Kensuke Kakiuchi, M.D.¹⁾, Takafumi Hosokawa, M.D., Ph.D.¹⁾, Maki Kagitani, M.D., Ph.D.²⁾, Shimon Ishida, M.D., Ph.D.¹⁾ and Shigeki Arawaka, M.D., Ph.D.¹⁾

¹⁾ Department of Internal Medicine IV, Division of Neurology, Osaka Medical and Pharmaceutical University
²⁾ Blood Purification Center, Osaka Medical and Pharmaceutical University

The patient is an 18-year-old female. She had a history of acute disseminated encephalomyelitis at the age of 6 and 7. She visited our hospital due to acute disturbance of consciousness, quadriplegia, and numbness of left upper and lower extremities. Brain MRI showed multiple DWI/FLAIR high-signal lesions in the bilateral cerebral hemispheres, cerebellum, and brainstem. Qualitative test indicated that serum anti-MOG antibodies was positive, and she was diagnosed with anti-MOG antibody-positive polyphasic disseminated encephalomyelitis. Intravenous mPSL pulse therapy was performed twice, but the symptoms worsened. As a second line treatment, plasma exchange was started. However, she developed transfusion related acute lung injury. Alternatively, she was treated with immunoadsorption plasmapheresis. Her symptoms were significantly improved. This case seems to be valuable because there are few reports showing effectiveness of immunoadsorption therapy on anti-MOG antibody-related diseases, especially for polyphasic disseminated encephalomyelitis.
Full Text of this Article in Japanese PDF (1149K)

(CLINICA NEUROL, 63: 518−522, 2023)
key words: anti-myelin oligodendrocyte glycoprotein antibody (MOG antibody), multiphasic disseminated encephalomyelitis (MDEM), acute disseminated encephalomyelitis (ADEM), apheresis, immunoadsorption plasmapheresis

(Received: 5-Apr-23)