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• Vol.63 No.8
• CLINICA NEUROL, 63: 497−504, 2023
• Vol.63 No.8 contents

Review

Autoimmune encephalitis and paraneoplastic neurological syndromes presenting atypical parkinsonism: a scoping review

Naoki Yamahara, M.D.¹⁾, Akio Kimura, M.D., Ph.D.¹⁾ and Takayoshi Shimohata, M.D., Ph.D¹⁾

¹⁾ Department of Neurology, Gifu University Graduate School of Medicine

Recent studies have demonstrated that atypical parkinsonism can be presented in autoimmune encephalitis and paraneoplastic neurological syndromes. However, it is unclear which anti-neural antibodies are involved and when these diseases should be suspected. To address these clinical questions, we conducted a scoping review and analyzed 38 articles. The literature shows that many anti-neural antibodies, including unknown ones, have been reported in progressive supranuclear palsy, corticobasal syndrome, and multiple system atrophy. Moreover, the following symptoms and signs suggest the possibility of autoimmune encephalitis and paraneoplastic neurological syndromes: early onset, acute or subacute progression, the presence of a neoplasm, significant weight loss, abnormal cerebrospinal fluid findings, the absence of typical brain magnetic resonance imaging findings, and the existence of atypical physical examination signs.
Full Text of this Article in Japanese PDF (615K)

(CLINICA NEUROL, 63: 497−504, 2023)
key words: progressive supranuclear palsy, corticobasal syndrome, multiple system atrophy, anti-neural antibody, scoping review

(Received: 11-Apr-23)