Rinsho Shinkeigaku (Clinical Neurology)

Case Report

A case of autoimmune encephalitis with involuntary movements as the first symptom and suspected association with mumps virus infection

Masashi Hoshino, M.D., Ph.D.1)2) , Rie Sasaki, M.D., Ph.D.1)2), Yoko Tsuchihashi, M.D., Ph.D.1)2), Yoshinobu Otsuka, M.D., Ph.D.1)2), Kenzo Sakurai, M.D., Ph.D.2) and Yoshihisa Yamano, M.D., Ph.D.2)

Corresponding author: Division of Neurology, Machida Municipal Hospital [Machida, Tokyo 194-0023, Japan]
1) Division of Neurology, Machida Municipal Hospital
2) Department of Internal Medicine, Division of Neurology, St. Marianna University School of Medicine

This case involved a 72-year-old woman. From the day after mitral annuloplasty, a fever over 37°C and ballismus-like involuntary movements of the right upper and lower limbs appeared. A few month later, involuntary movements spread throughout the body, and she developed impairment of consciousness and difficulty speaking and eating. Levels of protein in cerebrospinal fluid were high. Positive results were seen for serum mumps immunoglobulin G and M antibody. Because steroid pulse therapy proved effective, we suspected autoimmune encephalitis associated with mumps virus infection.
Full Text of this Article in Japanese PDF (966K)

(CLINICA NEUROL, 62: 140|144, 2022)
key words: involuntary movement, mumps virus, autoimmune encephalitis, steroid pulse therapy

(Received: 15-Jul-21)