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• Vol.60 No.3
• CLINICA NEUROL, 60: 187−192, 2020
• Vol.60 No.3 contents

Case Report

Amyloid β-related angiitis presenting extensive brain involvement without detection of hemorrhagic lesions: A case report

Yuya Hatano, M.D.¹⁾, Akihiro Sugai, M.D., Ph.D.¹⁾, Takuma Yamagishi, M.D.¹⁾, Akihiro Nakajima, M.D.¹⁾, Akiyoshi Kakita, M.D., Ph.D.²⁾ and Osamu Onodera, M.D., Ph.D.¹⁾

¹⁾Department of Neurology, Brain Research Institute, Niigata University
²⁾Department of Pathology, Brain Research Institute, Niigata University

In amyloid β-related angiitis, cortical or subcortical microbleeding or cortical superficial siderosis supports clinical diagnosis. However, here we present a 75-year-old female case of amyloid β-related angiitis that did not initially show these lesions. The patient developed right homonymous hemianopia and aphasia, and subsequently became comatose. Her brain lesions progressed extensively from the left occipital lobe to the bilateral cerebral hemispheres, with diffused leptomeningeal lesions and scattered DWI high-intensity lesions. After pathological diagnosis, steroid treatment improved her symptoms as well as imaging findings. No hemorrhagic lesions were detected in the T₂^*-weighted imaging performed before treatment. However, susceptibility-weighted imaging performed after treatment showed a number of lesions with microbleeding. The clinical features of amyloid β-related angiitis that do not show hemorrhagic lesions at onset should be investigated for rapid therapeutic intervention in the future.
Full Text of this Article in Japanese PDF (834K)

(CLINICA NEUROL, 60: 187−192, 2020)
key words: amyloid β-related angiitis, leptomeningeal legion, microbleeding, T₂^*-weighted imaging, susceptibility-weighted imaging

(Received: 28-Jun-19)