Rinsho Shinkeigaku (Clinical Neurology)

Case Report

A case of suspected neuromyelitis optica spectrum disorder preceded by aseptic meningitis-like symptoms

Kiyomi Odachi, M.D., Ph.D.1)2), Koutarou Iio, M.D.3), Kenichirou Uno, M.D.1), Norikazu Kawada, M.D.1) and Hidekazu Tomimoto, M.D., Ph.D.4)

1)Department of Neurology, Matsusaka Central General Hospital
2)Department of Neurology, Kuwana City Medical Center
3)Department of Cardiology, Matsusaka Central General Hospital
4)Department of Neurology, Mie University Graduate School of Medicine

A 20-year-old woman was hospitalized after experiencing headaches, high fever, and nausea for 1 week. She was conscious and had no abnormal neurological findings or neck stiffness. Examination of her cerebrospinal fluid showed a pronounced elevation of mononuclear cells. She was admitted to our hospital with the diagnosis of meningitis and had hypersomnia 3 days later. Brain MRI (FLAIR) demonstrated high-intensity lesions at the dorsal pons, and bilateral hypothalamus and spinal MRI demonstrated longitudinal T2 high-intensity lesions extending from C2 to C4 and from C6 to Th6. We suspected neuromyelitis optica spectrum disorder (NMOSD) and administered intravenous methylprednisolone after which her symptoms and MRI abnormalities improved immediately. Serum anti-aquaporin-4 antibody and antimyelin oligodendrocyte glycoprotein antibody were negative. Thus, it is important to perform MRI imaging early in the onset of aseptic meningitis due to numerous case reports of patients diagnosed with neuromyelitis optica or NMOSD with initial meningitis-like symptoms.
Full Text of this Article in Japanese PDF (2055K)

(CLINICA NEUROL, 59: 736|739, 2019)
key words: neuromyelitis optica spectrum disorder, meningitis, hypothalamus

(Received: 9-May-19)