Rinsho Shinkeigaku (Clinical Neurology)

Brief Clinical Note

Acute myelitis associated with anti-neutral glycolipid antibody

Hideo Terasawa, M.D., Ph.D.1), Hirotaka Shimuzu, M.D., Ph.D.1), Toshiyuki Uehara, M.D., Ph.D.1), Yasushi Kita, M.D., Ph.D.1), Sayuri Shima, M.D., Ph.D.2) and Tatsuro Mutoh, M.D., Ph.D.2)

1)Department of Neurology, Hyogo Brain and Heart Center at Himeji
2)Department of Neurology, Fujita Health University, School of Medicine

A 48-year-old man with rapid onset of fever elevation developed acute myelitis over a period of a week. MRI of the spinal cord revealed a longitudinal T2-hyperintense intraspinal lesion extending from C6 to Th8 level. Clinical symptoms and findings resolved with immunotherapy. In serological analysis, no antibodies related to various collagen diseases, anti-aquaporin-4 (AQP4) antibody and anti-myelin oligodendrocyte glycoprotein (MOG) antibody were detected. Antilactosylceramide (LacCer) antibodies were detected in the acute phase of serum and cerebrospinal fluid, with titers showing decrements in the recovery phase. The present case supports the notion that acute myelitis can occur as an anti-neutral glycolipid antibody-related disorder. Anti-neutral glycolipid antibodies should be examined in future pertinent cases of myelitis.
Full Text of this Article in Japanese PDF (574K)

(CLINICA NEUROL, 59: 33|36, 2019)
key words: myelitis, acute disseminated encephalomyelitis (ADEM), anti-neutral glycolipid antibody

(Received: 24-Aug-18)