Rinsho Shinkeigaku (Clinical Neurology)

Case Report

Anti-Hu antibody positive sensory neuronopathy causing painful legs and moving toes (PLMT) in a 75-year-old female with small cell lung cancer (SCLC)

Yuki Tsujimoto, M.D.1), Akihito Hao, M.D.1)3), Tatsuya Sato, M.D.1), Takuto Hideyama, M.D., Ph.D.1), Hideki Shibuya, M.D., Ph.D.2) and Yasushi Shiio, M.D., Ph.D.1)

1)Department of Neurology, Tokyo Teishin Hospital
2)Department of Respiratory Medicine, Tokyo Teishin Hospital
3)Present address: Department of Neurology, Graduate School of Medicine, University of Tokyo

The case is a 75-year-old female. She had dysesthesia in the distal extremities and truncal ataxia, and they had progressed in two months. Neurological examination revealed the findings of segmental dysesthesia in the distal extremities, impaired deep sensations in the trunk and four limbs, and painful legs and moving toes (PLMT). After workup, she was diagnosed with small cell lung cancer and her blood sample was positive for anti-Hu antibody. We concluded that her neurological symptoms were attributable to sensory neuronopathy associated with paraneoplastic syndrome. No cases with PLMT caused by paraneoplastic syndrome have been reported so far. She had chemotherapy to lung cancer and Duloxetine without improvement of PLMT. On the other hand, intravenous immunoglobulin treatment improved lightening pain in the toes without improvement of moving toes.
Full Text of this Article in Japanese PDF (529K)

(CLINICA NEUROL, 58: 677|681, 2018)
key words: small cell lung cancer (SCLC), paraneoplastic syndrome, anti-Hu antibody, painful legs and moving toes (PLMT)

(Received: 3-Jul-18)