Rinsho Shinkeigaku (Clinical Neurology)

Case Report

An anti-RNP antibody-positive case of aseptic meningitis induced by non-steroidal anti-inflammatory drugs in a young woman

Taro Matsui, M.D.1), Keiichi Nakagawa, M.D.1), Keishi Yamazaki, M.D.1), Taishi Wada, M.D.1), Masato Kadoya, M.D.1) and Kenichi Kaida, M.D., Ph.D.1)

1)Department of Neurology, Anti-aging and Vascular Medicine, National Defense Medical College

A 19-year-old woman developed high fever, headache, and nausea after taking Loxoprofen for pharyngitis, followed by disturbed consciousness and nuchal stiffness. The patient and her mother had a history of Raynaud's phenomenon. Cerebrospinal fluid (CSF) examination indicated a diagnosis of aseptic meningitis and revealed high levels of Q albumin and IgG index. Anti-RNP antibodies were positive in serum and CSF. Her symptoms disappeared immediately after cessation of Loxoprofen and a drug lymphocyte stimulation test was negative, confirming a diagnosis of non-steroidal anti-inflammatory drugs (NSAIDs)-induced aseptic meningitis. It should be kept in mind that an immune abnormality such as serum and CSF anti-RNP antibodies may play a role in development of NSAIDs-induced aseptic meningitis. A history of usage of NSAIDs and a thorough examination of collagen diseases are useful for identification of the origin of aseptic meningitis in a young woman.
Full Text of this Article in Japanese PDF (434K)

(CLINICA NEUROL, 58: 25|29, 2018)
key words: aseptic meningitis, anti-RNP antibody, Loxoprofen, non-steroidal anti-inflammatory drugs (NSAIDs), collagen disease

(Received: 7-Aug-17)