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• Vol.58 No.1
• CLINICA NEUROL, 58: 25−29, 2018
• Vol.58 No.1 contents

Case Report

An anti-RNP antibody-positive case of aseptic meningitis induced by non-steroidal anti-inflammatory drugs in a young woman

Taro Matsui, M.D.¹⁾, Keiichi Nakagawa, M.D.¹⁾, Keishi Yamazaki, M.D.¹⁾, Taishi Wada, M.D.¹⁾, Masato Kadoya, M.D.¹⁾ and Kenichi Kaida, M.D., Ph.D.¹⁾

¹⁾Department of Neurology, Anti-aging and Vascular Medicine, National Defense Medical College

A 19-year-old woman developed high fever, headache, and nausea after taking Loxoprofen for pharyngitis, followed by disturbed consciousness and nuchal stiffness. The patient and her mother had a history of Raynaud's phenomenon. Cerebrospinal fluid (CSF) examination indicated a diagnosis of aseptic meningitis and revealed high levels of Q albumin and IgG index. Anti-RNP antibodies were positive in serum and CSF. Her symptoms disappeared immediately after cessation of Loxoprofen and a drug lymphocyte stimulation test was negative, confirming a diagnosis of non-steroidal anti-inflammatory drugs (NSAIDs)-induced aseptic meningitis. It should be kept in mind that an immune abnormality such as serum and CSF anti-RNP antibodies may play a role in development of NSAIDs-induced aseptic meningitis. A history of usage of NSAIDs and a thorough examination of collagen diseases are useful for identification of the origin of aseptic meningitis in a young woman.
Full Text of this Article in Japanese PDF (434K)

(CLINICA NEUROL, 58: 25−29, 2018)
key words: aseptic meningitis, anti-RNP antibody, Loxoprofen, non-steroidal anti-inflammatory drugs (NSAIDs), collagen disease

(Received: 7-Aug-17)