Rinsho Shinkeigaku (Clinical Neurology)

Brief Clinical Note

Intracerebral hemorrhage after intravenous recombinant tissue plasminogen activator (rt-PA) therapy for acute cerebral infarction in a patient with ANCA-associated vasculitis

Noriko Akutagawa, M.D.1), Shoko Sadashima, M.D.1), Hideaki Nakagaki, M.D.1), Sukehisa Nagano, M.D.1) and Takeo Yoshimura, M.D., Ph.D.1)

1)Department of Neurology, Fukuoka City Hospital

We report the case of a 68-year-old man who suddenly developed right hemiparesis. MRI of the brain revealed a new infarction in the left corona radiata, and intravenous rt-PA was administered 100 minutes after the onset of symptoms. After the rt-PA infusion was started, his consciousness declined and the CT revealed bilateral intracerebral hemorrhage. His consciousness did not improve thereafter. He was diagnosed with ANCA-associated vasculitis owing to the high levels of MPO-ANCA and urinary protein and the presence of erythrocytes without any other cause of renal damage. Although ANCA-associated vasculitis rarely involves the central nervous system, intracerebral hemorrhage as well as cerebral infarction may occur. This case provides an important opportunity to explore the implications of intravenous rt-PA therapy for acute cerebral infarction in patients with ANCA-associated vasculitis.
Full Text of this Article in Japanese PDF (452K)

(CLINICA NEUROL, 57: 454|456, 2017)
key words: ANCA-associated vasculitis, rt-PA, MPO-ANCA, intracerebral hemorrhage, cerebral infarction

(Received: 8-Feb-17)