Rinsho Shinkeigaku (Clinical Neurology)

Case Report

A case of primary central nervous system anaplastic lymphoma kinase positive anaplastic large cell lymphoma manifested as a unilateral pachymeningits

Etsuco Fujisawa, M.D.1), Hidehiro Shibayama, M.D.1), Fumi Mitobe, M.D.1), Fumiaki Katada, M.D.1), Susumu Sato, M.D.1) and Toshio Fukutake M.D., Ph.D.1)

1)Department of Neurology, Kameda Medical Center

There have been 23 reports of primary central nervous system anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma in the literature. Here we report the 24th case of a 40-year-old man who presented with occipital headache for one month. His contrast-enhanced brain MRI showed enhancement around the right temporal lobe, which suggested a diagnosis of hypertrophic pachymeningitis. He improved with steroid therapy. After discharge, however, he was readmitted with generalized convulsive seizures. Finally, he was diagnosed as primary central nervous system ALK-positive anaplastic large cell lymphoma by brain biopsy. Primary central nervous system lymphoma invading dura matter can rarely manifests as a unilateral pachymeningitis. Therefore, in case of pachymeningitis, we should pay attention to the possibility of infiltration of lymophoma with meticulous clinical follow-up.
Full Text of this Article in Japanese PDF (649K)

(CLINICA NEUROL, 57: 705|710, 2017)
key words: primary central nervous system lymphoma, anaplastic lymphoma kinase (ALK) positive anaplastic large cell lymphoma, pachy meningitis

(Received: 19-Mar-17)