Rinsho Shinkeigaku (Clinical Neurology)


Epilepsy and ion channels

Yoshihiro Sugiura, M.D., Ph.D.1) and Yoshikazu Ugawa, M.D., Ph.D.1)

1)Department of Neurology, Fukushima Medical University School of Medicine

Many mutations of genes for ion channels result in some epilepsies. Their electrophysiological studies reveal pathophysiological mechanisms underlining epilepsy and also mechanism of action of several antiepileptic drugs. In this review, We briefly summarize pathophysiology of epilepsy and the mechanisms of antiepileptic drugs.
Full Text of this Article in Japanese PDF (533K)

(CLINICA NEUROL, 57: 1|8, 2017)
key words: epilepsy, ion channel, glutamate receptor, GABA receptor

(Received: 12-Sep-16)