Rinsho Shinkeigaku (Clinical Neurology)

Brief Clinical Note

Myopericarditis in a case of anti-signal recognition particle (anti-SRP) antibody-positive myopathy

Mariko Tanaka, M.D.1), Naoki Gamou, M.D.1), Hirohiko Shizukawa, M.D.1), Emiko Tsuda, M.D., Ph.D.2) and Shun Shimohama, M.D., Ph.D.2)

1)Department of Neurology, Sapporo Kosei General Hospital
2)Department of Neurology, Sapporo Medical University School of Medicine

A 79 year-old female was admitted to our hospital because of high serum creatine kinase level together with proximal muscle weakness and pain on grasping. MRI revealed inflammatory changes in femoral muscles on both sides. Muscle biopsy showed size irregularity of muscle cells, and necrosis and regeneration of fibers. Study of antibodies was also consistent with the diagnostic criteria of anti-signal recognition particle (anti-SRP) antibody-positive myopathy. On admission, the patient required pericardiocentesis for the management of exudative pericarditis. Accompanying the aggravation of myositis, negative T wave in precordial leads on ECG, ventricular extrasystoles and non-sustained ventricular tachycardia were observed. These abnormalities were resolved with the improvement of myositis by immunosuppressive treatment. These observations suggest that the myopericarditis was associated with anti-SRP antibody-positive myopathy.
Full Text of this Article in Japanese PDF (656K)

(CLINICA NEUROL, 56: 862|865, 2016)
key words: anti-SRP antibody, myopathy, myocarditis, pericarditis, ECG abnormality

(Received: 24-May-16)