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• Vol.55 No.10
• CLINICA NEUROL, 55: 728−731, 2015
• Vol.55 No.10 contents

Case Report

A case of pure alexia and foreign accent syndrome following acute encephalopathy in the presence of anti-glutamate receptor antibodies

Naoki Tokuda, M.D.¹⁾, Masaki Kondo, M.D., Ph.D.¹⁾, Takashi Kasai, M.D., Ph.D.¹⁾,Ayaka Kimura, M.D.¹⁾, Masahiro Nakagawa, M.D., Ph.D.²⁾ and Toshiki Mizuno, M.D., Ph.D.¹⁾

¹⁾Department of Neurology, Kyoto Prefectural University of Medicine, Graduate School of Medicine
²⁾North Medical Center, Kyoto Prefectural University of Medicine, Graduate School of Medicine

A 41-year-old right-handed woman presented abnormal behavior two weeks after suffering from headache and fever. Anti-glutamate receptor antibodies in the serum and cerebrospinal fluid were positive and we diagnosed anti-glutamate receptor antibody-related encephalopathy. The patient improved after administration of corticosteroid and was discharged without neurological deficit. After discharge, pure alexia and foreign accent syndrome-like language disturbance appeared consecutively. The serial fluorodeoxyglucose-positron emission tomography scans suggested that pure alexia and FASlike language disturbance may have been caused by low function of the occipital lobes and the left frontal lobe, respectively. FAS has been linked to various lesions in the brain. The background mechanism may therefore be heterogeneous. On the other hand, patients with this syndrome recover spontaneously with our case. FAS may therefore be a temporal phenomenon resulting from imbalance in language processing rather than a specific deficit.
Full Text of this Article in Japanese PDF (511K)

(CLINICA NEUROL, 55: 728−731, 2015)
key words: anti-glutamate receptor antibody, encephalopathy, FDG-PET, foreign accent syndrome, pure alexia

(Received: 10-Mar-15)