Rinsho Shinkeigaku (Clinical Neurology)

Case Report

A case of dermatomyositis with anti-CADM-140 antibody and alveolar hemorrhage

Kenta Sato, M.D.1), Saori Morozumi, M.D.2), Yuko Takeuchi, M.D.1), Jun Ochiai, M.D.1) and Chiyuki Mabuchi, M.D.1)

1)Department of Neurology, Nagoya Ekisaikai Hospital
2)Department of Neurology, Nagoya Daini Red Cross Hospital

A-47-year-old woman was admitted to our hospital because of eruption, severe arthritis, myalgia, pharyngalgia and the elevation of serum creatine kinase. She was diagnosed with dermatomyositis based on a biopsied specimen and clinical symptoms. Serum anti CADM-140 antibody was detected by immunoprecipitation. Pulse therapy with methylprednisolone and cyclophophamide could transiently improve myalgia and so on, but she died of rapidly progressive interstitial lung disease. Autopsy findings demonstrated diffuse alveolar damage and alveolar hemorrhage. It is said that patients with anti CADM-140 antibody show poor muscle symptoms and alveolar hemorrhage has been described very rarely. This patient is the rare case of dermatomyositis with anti CADM-140 antibody developing severe muscle symptoms, pharyngalgia and aleveolar hemorrhage in autopsy findings.
Full Text of this Article in Japanese PDF (11131K)

(CLINICA NEUROL, 54: 408|412, 2014)
key words: anti CADM-140 antibody, dermatomyositis, interstitial pneumonia, alveolar hemorrhage

(Received: 8-May-13)