Rinsho Shinkeigaku (Clinical Neurology)

Symposium 05

Intrathecal baclofen therapy for hereditary spastic paraplegia

Takaomi Taira, M.D., Ph.D.1) and Nobuhiko Takeda, M.D.1)

1)Department of Neurosurgery, Tokyo Women's Medical University

Intrathecal baclofen therapy (ITB) is an established treatment for intractable spasticity. More than 1,100 patients have undergone ITB in Japan, and there are about 50 hereditary spastic paraplegia (HSP) The features of ITB in HSP are 1. small doses of baclofen may often be enough, 2. small changes of doses later the symptoms remarkably, 3. doses can be decreased after long term ITB.
Full Text of this Article in Japanese PDF (280K)

(CLINICA NEUROL, 54: 1018|1020, 2014)
key words: baclofen, spasticity, hereditary spastic paraplegia

(Received: 21-May-14)