Rinsho Shinkeigaku (Clinical Neurology)

Case Report

A case of neuromyelitis optica spectrum disorder developing a fulminant course with multiple white-matter lesions following fingolimod treatment

Shoko Izaki, M.D.1), Shinya Narukawa, M.D.1), Akihiro Kubota, M.D.1), Takao Mitsui, M.D.1), Hikoaki Fukaura, Ph.D.1) and Kyoichi Nomura, Ph.D.1)

1)Department of Neurology, Saitama Medical Center

A 49-year-old female neuromyelitis optica spectrum disorder (NMOSD) patient with positive anti-aquaporin 4 (AQP4) antibody was treated with fingolimod (FTY720). Ten days later, she developed acute disturbance of consciousness, aphasia, right hemi-spatial neglect, and right hemiparesis. Brain MRI showed multiple white-matter lesions with slight Gadolinium enhancement. She was diagnosed of acute exacerbation of NMOSD. Thus, fingolimod may be associated with the development of a fulminant course in NMOSD patients with positive anti-AQP4 antibody
Full Text of this Article in Japanese PDF (2141K)

(CLINICA NEUROL, 53: 513|517, 2013)
key words: neuromyelitis optica spectrum disorder, fingolimod (FTY720), anti-AQP4 antibody, multiple sclerosis

(Received: 22-Aug-12)