Rinsho Shinkeigaku (Clinical Neurology)

Symposium 4

Cognitive adverse effects of anticholinergic medication for overactive bladder in PD/DLB

Ryuji Sakakibara, M.D., Ph.D.1)

1)Neurology, Sakura Medical Center, Toho University

Overactive bladder (OAB) is a common autonomic disorder due mostly to lesions in the micturition-inhibiting area (D1 dopaminergic pathway in the basal ganglia) in Parkinson's disease (PD) and dementia with Lewy bodies (DLB). anticholinergic drugs are the mainstay in the treatment of OAB. However, since 1997, anticholinergic adverse events on the cognitive function have been recognized. Drugs with less lipophilic, less permeable through the blood-brain barrier are the choice in the treatment of OAB in elderly neurologic patients.
Full Text of this Article in Japanese PDF (1198K)

(CLINICA NEUROL, 53: 1389|1392, 2013)
key words: cognitive function, anticholinergic drug, overactive bladder, Parkinson's disease, dementia with Lewy bodies

(Received: 1-Jun-13)