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• Vol.53 No.11
• CLINICA NEUROL, 53: 1087−1090, 2013
• Vol.53 No.11 contents

Symposium 2

Cutting-edge MRI techniques for studying neurological diseases focusing on spinocerebellar degeneration

Hirohisa Watanabe, M.D.¹⁾, Joe Senda, M.D.¹⁾, Mizuki Ito, M.D.¹⁾, Naoki Atsuta, M.D.¹⁾, Kazuhiro Haram, M.D.¹⁾, Hazuki Watanabe¹⁾, Ryoichi Nakamura, M.D.¹⁾, Takashi Tsuboi, M.D.¹⁾, Mari Yoshida, M.D.²⁾, Shinji Naganawa, M.D.³⁾ and Gen Sobue, M.D.¹⁾

¹⁾Department of Neurology, Nagoya University Graduate School of Medicine
²⁾Institute for Medical Science of Aging, Aichi Medical University
³⁾Department of Radiology, Nagoya University Graduate School of Medicine

This symposium discusses the utility of the different MR techniques in the diagnosis and management of spinocerebellar degeneration (SCD). Conventional MRI is widely used and can show characteristic signal abnormalities such as putaminal hyperintensity, hyperintense putaminal rim, putaminal hypointensity, hot cross bun sign in the pontine base, and hyperintensity in the middle cerebellar peduncles strengthening a diagnosis of multiple system atrophy (MSA). However, the diagnostic utility of these signal abnormalities in early MSA remains restricted. In addition, it should be considered that different magnetic field strengths and sequences could be influenced on the findings resulting false negative. On the other hand, proton magnetic resonance spectroscopy, diffusion weighted imaging (DWI), diffusion tensor imaging (DTI) and voxel based morphometry (VBM) in the pontine base, cerebellum, and putamen will be informative in the early diagnosis of MSA and other SCD prior to conventional MRI changes and even before any clinical manifestation of symptoms. Particularly, DWI, DTI, and VBM are expected to have potential as surrogate markers of disease progression. Further prospective and large studies including earlier disease stages will be needed to clarify whether these novel MR techniques will aid in the future sets of diagnostic criteria and therapeutic trials.
Full Text of this Article in Japanese PDF (2010K)

(CLINICA NEUROL, 53: 1087−1090, 2013)
key words: MRI, diffusion MRI, voxel based morphometry, MR spectroscopy, multiple system atrophy

(Received: 30-May-13)