Rinsho Shinkeigaku (Clinical Neurology)

Brief Clinical Note

A case of acute ophthalmoparesis with gaze nystagmus

Naomi Ikuta, M.D.1), Yukiko Tada, M.D.1) and Michiaki Koga, M.D.2)

1)Department of Neurology, Ube-Kousan Central Hospital
2)Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine

A 61-year-old man developed double vision subsequent to diarrheal illness. Mixed horizontal-vertical gaze palsy in both eyes, diminution of tendon reflexes, and gaze nystagmus were noted. His horizontal gaze palsy was accompanied by gaze nystagmus in the abducent direction, indicative of the disturbance in central nervous system. Neither limb weakness nor ataxia was noted. Serum anti-GQ1b antibody was detected. Brain magnetic resonance imaging (MRI) findings were normal. The patient was diagnosed as having acute ophthalmoparesis. The ophthalmoparesis and nystagmus gradually disappeared in 3 months. The accompanying nystagmus suggests that central nervous system disturbance may also be present with acute ophthalmoparesis.
Full Text of this Article in Japanese PDF (262K)

(CLINICA NEUROL, 52: 433|435, 2012)
key words: acute ophthalmoparesis, gaze nystagmus, anti-GQ1b antibody, central nervous system lesion

(Received: 20-Nov-11)