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• Vol.50 No.10
• CLINICA NEUROL, 50: 728−731, 2010
• Vol.50 No.10 contents

Brief Clinical Note

A case of subacute necrotizing lymphadenitis with recurrent aseptic meningitis associated with persistent high titer of anti-nuclear antibody occurring over a short period of time

Taiji Yamashita, M.D.¹⁾, Kenichi Shibata, M.D.¹⁾, Sukehisa Nagano, M.D.¹⁾, Shinichi Aishima, M.D.²⁾ and Takeo Yoshimura, M.D.¹⁾

¹⁾Department of Neurology, Fukuoka City Hospital
²⁾Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University

A 35-year-old woman developed recurrent aseptic meningitis three times over a period of 16 months. Each episode followed swelling of her cervical lymph nodes. During the third episode, microscopic findings of biopsied specimens from a cervical lymph node indicated subacute necrotizing lymphadenitis (SNL). While she responded poorly to NSAIDs, steroids rapidly improved her fever, headache and swollen lymph nodes. Since the first episode, anti-nuclear antibody (ANA) and anti-SS-A antibody was positive and the titer of ANA increased with each episode. SNL is a benign and self-limited disease, and the appearance of autoantibodies is usually transient. It is possible that a persistent immune abnormality is related to recurrences of aseptic meningitis with SNL.
Full Text of this Article in Japanese PDF (681K)

(CLINICA NEUROL, 50: 728−731, 2010)
key words: subacute necrotizing lymphadenitis, recurrent aseptic meningitis, anti-nucleotide antibody, systemic lupus erythematosus

(Received: 8-May-10)