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• Vol.48 No.3
• CLINICA NEUROL, 48: 173−178, 2008
• Vol.48 No.3 contents

Original Article

Clinical features and courses of 5 cases with HIV encephalopathy

Rina Hashimoto, M.D.¹⁾, Eiichiro Mukai, M.D.¹⁾, Yoshiyuki Yokomaku, M.D.²⁾, Naoto Mamiya, M.D.²⁾ and Motohiro Hamaguchi, M.D.³⁾

¹⁾Department of Neurology, National Hospital Organization Nagoya Medical Center
²⁾Department of Infectious Disease, National Hospital Organization Nagoya Medical Center
³⁾Department of Clinical Reseach Center, National Hospital Organization Nagoya Medical Center

Clinical features and courses of 5 cases with HIV encephalopathy were reported. The subjects were among the patients registered as HIV patients at the Nagoya Medical Center, between 1996 and 2005. There were 458 patients with HIV infection including 127 cases of AIDS. All patients suffered from severe immunological deficiency when HIV encephalopathy developed. Other opportunistic infections had also occurred in three patients. HIV encephalopathy was one of the presenting manifestations of HIV infection in four patients, and no patients had received antiretroviral therapy. HAART improved motor disturbance and their ADL became independent except for one case. Improvements in neuropsychological examination scores were noted in all cases. Recovery from psychiatric symptoms, however, was incomplete. Four patients could not work, and 3 needed psychological treatment due to behavioral abnormalities. HIV encephalopathy is not a lethal disease but the functional prognosis was very poor. New therapy is needed for HIV encephalopathy.
Full Text of this Article in Japanese PDF (517K)

(CLINICA NEUROL, 48: 173−178, 2008)
key words: HIV, AIDS, cognitive impairment, behavioral change, prognosis

(Received: 11-May-07)