Rinsho Shinkeigaku (Clinical Neurology)

Original Article

Normalization of physical activity on acute ischemic stroke

Shoji Honda, M.D.1), Yuichiro Inatomi, M.D.1), Toshiro Yonehara, M.D.1), Shodo Fujioka, M.D.1), Yoichiro Hashimoto, M.D.2), Teruyuki Hirano, M.D.3) and Makoto Uchino, M.D.3)

1)Stroke Center, Saiseikai Kumamoto Hospital
2)Department of Neurology, Kumamoto City Hospital
3)Department of Neurology, Graduate School of Medical Sciences, Kumamoto University

The purpose of present study is to clarify the association between early normalization, orthostatic hypotension (OH) and neurological deterioration in patients with acute ischemic stroke. The authors retrospectively performed scheduled ambulation in 162 consecutive patients who were diagnosed as having ischemic stroke without them being comatose. Blood pressure and neurological findings were examined during the orthostatic tolerance test. OH was occurred in 86 (53.1%) of all patients. Neurological worsening were found in 22 of them during all clinical course, although worsening closely associated with orthostatic tolerance was only two of them. Significant OH was occurred in the patients with cerebral arterial stenosis on head-tilt 60° after 15 minutes (p=0.001). And the patients who have atrial fibrillation also yield OH on sitting immediately after (p=0.041) and 5 minutes after moving (p=0.035). Because symptomatic OH were rarely observed in the patients with acute ischemic stroke without them being comatose, early ambulation could be achieved safely.

(CLINICA NEUROL, 45: 279|286, 2005)
key words: acute ischemic stroke, orthostatic hypotension, early ambulation, normalization of physical activity

(Received: 2-Apr-04)