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• Vol.64 No.7
• CLINICA NEUROL, 64: 453−459, 2024
• Vol.64 No.7 contents

Invited Review

Memory impairments in temporal lobe epilepsy

Takahiko Mukaino, M.D., Ph.D.

Department of Neurology, Kyushu University Hospital

Temporal lobe epilepsy is known to present with various cognitive impairments, among which memory deficits are frequently reported by patients. Memory deficits can be classified into two types: classical hippocampal amnesia, which is characterized by abnormalities detected in neuropsychological assessments, and atypical memory deficits, such as accelerated long-term amnesia and autobiographical memory impairment, which cannot be identified using standard testing methods. These deficits are believed to arise from a complex interplay among structural brain abnormalities, interictal epileptic discharges, pharmacological factors, and psychological states. While fundamental treatments are limited, there are opportunities for interventions such as environmental adjustments and rehabilitation. This review article aims to provide a comprehensive overview of the types, underlying pathophysiology, and intervention methods for memory disorders observed in patients with temporal lobe epilepsy.
Full Text of this Article in PDF (802K)

(CLINICA NEUROL, 64: 453−459, 2024)
key words: temporal lobe epilepsy, memory impairment, cognitive dysfunction, accelerated long-term forgetting, pathophysiology

(Received: 9-May-23)