臨床神経学

<シンポジウム(3)―4―5>電気診断の復権

軸索興奮特性測定の臨床への貢献

金井 数明

千葉大学医学部附属病院神経内科
現 順天堂大学医学部脳神経内科〔〒113―8421 東京都文京区本郷2―1―1〕

Nerve excitability measurements are characteristic tests providing informations about the membrane potential and biophysical properties of nerve axons. Recent advances in developing new methods have enabled several such measurements to be made on a nerve quickly, non-invasively, and reproducibly. Modern nerve excitability measurement can give us important informations of some nodal and paranodal sodium and potassium conductances, and it has been applied to clarification of molecular pathophysiology in motor and sensory axons in many diseases. Although nerve excitability measurement is difficult to be applied to the electrophysiological diagnosis of diseases, it has been applied to the electrophysiological therapy evaluations for some motor and sensory symptoms such as muscle clamp or dysesthesia. Furthermore, it is recently reported that it can be utilized as disease survival biomarker in amyotrophic lateral sclerosis. I make a brief review of recent advances in the field of clinical applications of nerve excitability measurements.
Full Text of this Article in Japanese PDF (197K)

(臨床神経, 52:1256−1258, 2012)
key words:神経軸索興奮性特性,multiple excitability measurements,イオン電流,疾患バイオマーカー

(受付日:2012年5月25日)