＜シンポジウム09―1＞皮質下性血管障害の病態と治療
皮質下血管性認知症；認知症疾患における位置づけ
冨本 秀和
三重大学大学院医学系研究科・神経病態内科学〔〒517―8507 三重県津市江戸橋2―174〕
Subcortical vascular dementia (SVD) is a subtype of vascular dementia which constitutes approximately half of vascular dementia in Japan. It is featured by hypertensive small vessel disease such as white matter lesions and lacunar infarctions. The clinical and pathological features of SVD are relatively uniform. White matter lesions may remain asymptomatic but may develop subcortical dementia and Parkinsonism, if neural network function is impaired severe enough. SVD and CAA are considered to be a subcortical and cortical counterpart of small vessel disease, respectively, and the latter is closely associated with Alzheimer's disease. Therapeutic strategy for SVD is classified to the remedies for vascular risk factors and anti-dementia treatment. Anti-choline esterase inhibitors and memantine may be beneficial for SVD patients, but are not approved as therapeutic agents for vascular dementia.
Full Text of this Article in Japanese PDF (485K)
(臨床神経, 51：940−942, 2011)
key words：皮質下血管性認知症，白質病変，Binswanger病，アルツハイマー病
（受付日：2011年5月19日）
