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  会員専用

• ホーム
• 51巻11号
• 臨床神経, 51：849−852, 2011
• 51巻11号目次

教育講演7

神経疾患と糖鎖生物学：新たな生命鎖の役割

武藤　多津郎

藤田保健衛生大学医学部脳神経内科学講座〔〒470―1192 愛知県豊明市沓掛町田楽ヶ窪1―98〕

Many researchers now recognize the importance of glycobiological research achievements. Glycosidecontaining substances such as proteins (glycoproteins) and lipids (glycosphingolipids) have been involved in many important and essential events for normal life. The production of glycoside residues of the proteins is only partially regulated by the genes. In this talk, I will make a brief description of what glycobiology can influence the future of neurological research arena and how glycoproteins and glycolipids affect the normal biology of the neurons. Furthermore, I will introduce you some evidences that many neurological disorders such as Alzheimer's disease and immune-mediated encephalitis have special relationships with glycobiological abnormalities. I also explain the structures and functions of lipid rafts, caveolae, and glycosynapse and their roles in the intracellular signal transduction and cell motility.
Full Text of this Article in Japanese PDF (446K)

(臨床神経, 51：849−852, 2011)
key words：脂質ラフト，神経栄養因子，Trk，シグナル伝達，ギランバレー症候群

（受付日：2011年5月19日）