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  会員専用

• ホーム
• 51巻11号
• 臨床神経, 51：1157−1159, 2011
• 51巻11号目次

＜シンポジウム32―2＞神経疾患に対する抗体療法

筋疾患に対する抗マイオスタチン抗体療法の開発と応用

砂田　芳秀

川崎医科大学神経内科学〔〒701―0192 倉敷市松島577〕

Myostatin, a member of the muscle-specific transforming growth factor (TGF)-β family, negatively regulates skeletal muscle growth. It inhibits muscle stem cell proliferation and differentiation, and attenuates adult muscle fiber protein accretion, resulting in decreased skeletal muscle mass. Thus it has been considered to be a therapeutic target of myopathies including muscular dystrophy. Notably, administration of a blocking antibody against myostatin ameliorated the pathophysiology of dystrophin-deficient mdx mice. Although a clinical trial of an antimyostatin antibody MYO-029 failed to achieve a significant outcome in patients with muscular dystrophies, various distinct approaches have been taken to establish anti-myostatin therapy including a myostatin decoy receptor ACE-031, a peptide drug derived from myostatin prodomain, small-molecule inhibitors against the myostatin receptor, a follistatin-derived peptibody inhibiting myostatin and myostatin siRNA with collagen-derived carrier particles. Clinical application of the anti-myostatin therapeutics for the treatment of patients with muscular dystrophy needs further evaluation of safety and specification of the target disease types among various muscular dystrophies.
Full Text of this Article in Japanese PDF (180K)

(臨床神経, 51：1157−1159, 2011)
key words：マイオスタチン，TGF-β，筋ジストロフィー

（受付日：2011年5月20日）