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  会員専用

• ホーム
• 51巻11号
• 臨床神経, 51：1047−1050, 2011
• 51巻11号目次

＜シンポジウム20―3＞難治性神経感染症update

亜急性硬化性全脳炎

細矢　光亮

福島県立医科大学医学部小児科〔〒960―1295 福島市光が丘1番地〕

Subacute sclerosing panencephalitis (SSPE) is a progressive and fatal central nervous system disorder that results from a persistent SSPE virus infection. The efficacy of inosine pranobex, an antiviral/immunomodulator agent, remains controversial. Intraventricular interferon-alpha combined with oral inosine pranobex slows the progressive course of SSPE, but does not cure the disease. We examined a wide variety of antiviral compounds for their inhibitory effects on SSPE virus strains in vitro and in vivo, and found that ribavirin had potent inhibitory activity against SSPE. We tried to treat SSPE patients first with high-dose intravenous ribavirin therapy, and then with intraventricular ribavirin therapy. Ribavirin therapy seemed to have a certain effect on clinical courses of patients with SSPE. To reach the conclusion that ribavirin therapy is clinically effective, clinical trials on many cases will be required.
Full Text of this Article in Japanese PDF (230K)

(臨床神経, 51：1047−1050, 2011)
key words：亜急性硬化性全脳炎，リバビリン，脳室内投与療法

（受付日：2011年5月20日）