臨床神経学

第50回日本神経学会総会

<シンポジウム11―4>プリオン病の最新トピックス
プリオン病の治療予防開発

堂浦 克美

東北大学大学院医学系研究科プリオン蛋白分子解析分野〔〒980-8575 宮城県仙台市青葉区星陵町2-1〕

There is no established treatment for prion diseases; however, recently several drug candidates, including pentosan polysulfate and doxycycline, have been clinically used on a trial basis to prevent accumulation of abnormal prion protein in the brain. So far the outcome of the trials is still very far from the goal where a complete cure of the diseases is expected. In order to bridge the gap between the reality and the ideal, the followings are suggested. First, combination therapy needs to be developed against multi-targets: inhibition of prion replication; degradation and scavengery of prion; inhibition of prion-related neurodegeneration. Secondly, preclinical diagnostic means, by which healthy prion-carriers can be revealed before the onset of the diseases, should be explored for earlier therapeutic interventions. The last is to disclose intrinsic disease susceptibility factors and environmental factors, both of which could solely or jointly facilitate in suppressing prion replication and disease progress. Exploitation of these items should be tough but will be deserved for overcoming the fatal diseases.
Full Text of this Article in Japanese PDF (206K)

(臨床神経, 49:946−948, 2009)
key words:治療, プリオン病, 多剤併用療法, 発症前診断, 疾患感受性

(受付日:2009年5月22日)