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  会員専用

• ホーム
• 49巻11号
• 臨床神経, 49：825−826, 2009
• 49巻11号目次

第50回日本神経学会総会

＜シンポジウム3―1＞中枢神経系の再生・次なる半世紀
iPS細胞技術と神経疾患研究

岡野　栄之

慶應義塾大学医学部生理学教室〔〒160-8582　新宿区信濃町35〕

Induced pluripotent stem (iPS) cells are pluripotent stem cells directly reprogrammed from cultured mouse fibroblast by introducing Oct3/4, Sox2, c-Myc, and Klf4. Cells obtained using this technology, which allows the ethical issues and immunological rejection associated with embryonic stem (ES) cells to be avoided, might be a clinically useful source for cell replacement therapies. We found that secondary neurospheres (SNSs) generated from various mouse iPS cell showed their neural differentiation capacity and teratoma formation after transplantation into the brain of immunodeficient NOD/SCID mice. We found that origin (source of somatic cells) of the iPS cells are the crucial determinant for the potential tumorigenicity of iPS-derived neural stem/progenitor cells and that their tumorigenicity results from the persistent presence of undifferentiated cells within the SNSs. Surprisingly, SNSs derived from c-Myc minus iPS cells generated without drug selection showed robust tumorigenesis, in spite of their potential to contribute adult chimeric mice without tumor formation. Furthermore, we examined whether the transplantation of non-tumorigenic Nanog-iPS-derived SNSs into mouse spinal cord injury (SCI) model could promote locomotor function recovery. As a result, we found that properly pre-evaluated iPS clone-derived neural stem/progenitor cells may be a promising cell source for future transplantation therapy of SCI.
Full Text of this Article in Japanese PDF (155K)

(臨床神経, 49：825−826, 2009)
key words：人工多能性幹細胞, 胚性幹細胞, 神経幹細胞, 脊髄損傷, 腫瘍形成能

（受付日：2009年5月21日）