臨床神経学

第48回日本神経学会総会

<シンポジウム10-2>機能回復神経学
深部脳刺激法による不随意運動治療

後藤 惠

徳島大学 大学院ヘルスバイオサイエンス研究部神経情報医学分野〔〒770-8503 徳島市蔵本町2丁目50-1〕

The introduction of deep brain stimulation (DBS) was a historical step forward for the treatment of advanced and medically intractable movement disorders that include Parkinson's disease, dystonias, essential tremor, and Holmes' tremor. DBS is able to modulate the target region electrically in a reversible and adjustable fashion in contrast to an irreversible and destructive lesioning procedure. In the treatment of movement disorders, the potential targets are the thalamic ventral intermediate nucleus (Vim), globus pallidus internus (GPi), subthalamic nucleus (STN), pedunculopontine nucleus (PPN), and thalamic Vo-complex nucleus. With the development of DBS technology and stereotactic neurosurgical techniques, its therapeutic efficacy has been increased while reducing surgical complications. DBS has become an established therapy for disabling movement disorders and is currently being used to treat neuropsychiatric disorders.

(臨床神経, 47:948−950, 2007)
key words:脳深部刺激術, 運動異常症

(受付日:2007年5月16日)