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• Vol.57 No.2
• CLINICA NEUROL, 57: 88−91, 2017
• Vol.57 No.2 contents

Brief Clinical Note

A case of pediatric multiple sclerosis presenting with a tumefactive demyelinating lesion

Hisakazu Majima, M.D.¹⁾²⁾, Tsuyoshi Ito, M.D., Ph.D.¹⁾ and Norihisa Koyama, M.D., Ph.D.¹⁾

¹⁾Department of Pediatrics, Toyohashi Municipal Hospital
²⁾Present address: Department of Pediatric Nephrology, Aichi Children's Health and Medical Center

Pediatric multiple sclerosis accompanied by a tumefactive demyelinating lesion (TDL) is extremely rare. Because it is very difficult to distinguish TDLs from neoplasms, invasive brain biopsies are required for a definitive diagnosis. MR spectroscopy (MRS) without brain biopsy was recently shown diagnostic in some patients with TDLs, based on the elevation of glutamate/glutamine peaks. This report describes the clinical course of a 9-year-old girl with multiple sclerosis following a TDL and discusses the usefulness of MRS and brain biopsies to diagnose TDLs.
Full Text of this Article in Japanese PDF (525K)

(CLINICA NEUROL, 57: 88−91, 2017)
key words: pediatric multiple sclerosis, brain biopsy, open ring enhancement, tumefactive demyelinating lesion, MR spectroscopy

(Received: 22-Jun-16)