Rinsho Shinkeigaku (Clinical Neurology)

Brief Clinical Note

Guillan-Barré syndrome following scrub typus: two case reports

Katsuya Sakai, M.D.1), Nobuyuki Ishii, M.D.1), Yuka Ebihara, M.D.1), Hitoshi Mochizuki, M.D., Ph.D.1), Kazutaka Shiomi, M.D., Ph.D.1) and Masamitsu Nakazato, M.D., Ph.D.1)

1)Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki

Case 1: A 66-year-old man was admitted because of progressive gait disturbance and dysphagia after developing red rash. He was diagnosed as Guillain-Barré syndrome (GBS) and treated by intravenous immunoglobulin therapy (IVIg). Two weeks later, he could swallow and walk without any abnormalities. Case 2: A 58-year-old woman was admitted because of gait disturbance, bilateral peripheral facial nerve palsies, and respiratory failure one week after developing fever and rash. She was diagnosed as GBS and treated with IVIg. She underwent mechanical ventilation, while she could wean off it one month later and her limb strengths improved. We confirmed both patients had scrub typhus by serological studies. Peripheral neuropathy is one of the complications of scrub typhus. In addition, this disease sometimes leads to severe GBS. GBS should be included in differential diagnosis when peripheral neuropathies develop in the course of treating scrub typhus, and we should keep in mind that scrub typhus is one of the causes of GBS.
Full Text of this Article in Japanese PDF (298K)

(CLINICA NEUROL, 56: 577|579, 2016)
key words: scrub typhus, Guillain-Barré syndrome, Orientia tsutsugamushi, Rickettsia

(Received: 4-Jan-16)