Rinsho Shinkeigaku (Clinical Neurology)

Brief Clinical Note

Malignant lymphoma presented as recurrent multiple cranial nerve palsy after spontaneous regression of oculomotor nerve palsy: A case report

Takahiko Hirose, M.D.1), Hideto Nakajima, M.D.1), Tarou Shigekiyo, M.D.1), Taiji Yokote, M.D.2), Shimon Ishida, M.D.1) and Fumiharu Kimura, M.D.1)

1)Division of Neurology, Department of Internal Medicine I, Osaka Medical College
2)Division of Hematology, Department of Internal Medicine I, Osaka Medical College

We report the case of a 62-year-old man who presented with malignant lymphoma as recurrent multiple cranial nerve palsy after spontaneous regression of oculomotor nerve palsy. He developed ptosis and diplopia due to right oculomotor nerve palsy. Brain MRI/MRA showed no abnormality, and he recovered with conservative medical management. Three months later, he showed diplopia due to right abducens nerve palsy and facial pain and trigeminal sensory loss. Neurological examination revealed multiple cranial nerve palsy involved cranial nerve III, V, IX, and X of the right side. Serum soluble interleukin-2 receptor levels were normal, and cerebrospinal fluid examination was unremarkable. Steroid and subsequent intravenous immunoglobulin therapy didn't improve his symptoms. Six weeks after his admission, he showed rapid enlargement of the cervical lymph node and the right tonsil, and post-contrast T1-weighted MRI showed enlargement and enhancement of the left infraorbital nerve, the bilateral cavernous sinus, the bilateral facial nerves, and the left trigeminal nerve. The histopathologic examination of the tonsil biopsy revealed diffuse large B cell lymphoma. The cause of these symptoms was thought to be infiltrating the cavernous sinus, and adjacent nerves. Spontaneous regression of malignant lymphoma is an exceptional event, but this possibility should be considered so as to the correct diagnosis and proper treatment.
Full Text of this Article in Japanese PDF (485K)

(CLINICA NEUROL, 56: 48|50, 2016)
key words: malignant lymphoma, oculomotor nerve palsy, recurrent multiple cranial nerve palsy, spontaneous regression

(Received: 17-Aug-15)