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• Vol.55 No.11
• CLINICA NEUROL, 55: 840−843, 2015
• Vol.55 No.11 contents

Case Report

Riluzole-induced interstitial pneumonia in a case with amyotrophic lateral sclerosis

Shinichi Takeshima, M.D.¹⁾, Shuichiro Neshige, M.D.¹⁾³⁾, Takahiro Himeno, M.D.²⁾, Kazuhiro Takamatsu, M.D.¹⁾, Yutaka Shimoe, M.D., Ph.D.¹⁾ and Masaru Kuriyama, M.D., Ph.D.¹⁾

¹⁾Department of Neurology, Brain Attack Center Ota Memorial Hospital
²⁾Oita Red Cross Hospital
³⁾Present Address: Department of Clinical Neuroscience & Therapeutics, Hiroshima University

A 74-year-old woman was clinically diagnosed with possible amyotrophic lateral sclerosis (ALS) and was administered 100 mg/day of riluzole. After 2 months, she developed dyspnea and experienced gradual difficulty walking. Chest computed tomography revealed ground-glass opacity and consolidation in the lower lobes of both the lungs, thereby suggesting a diagnosis of interstitial pneumonia. Because the condition was suspected to be drug-induced, riluzole administration was discontinued and steroid (methylprednisolone) pulse therapy (1,000 mg/day, 3 days) was started. Her symptoms and radiological findings improved immediately. At 16 months later, she wanted to take riluzole again. She had the similar interstitial pneumonia on the 4^th day of the re-administration. Drug (riluzole)-induced lymphocyte stimulation tests (DLST) were negative two times. The symptoms of interstitial pneumonia, a rare adverse effect of riluzole, are very similar to worsening symptoms of ALS; therefore, patients with ALS receiving riluzole therapy should be carefully monitored.
Full Text of this Article in Japanese PDF (515K)

(CLINICA NEUROL, 55: 840−843, 2015)
key words: riluzole, adverse effect, interstitial pneumonia, amyotrophic lateral sclerosis

(Received: 7-May-15)