Rinsho Shinkeigaku (Clinical Neurology)

Brief Clinical Note

A case of post-transfusion posterior reversible encephalopathy syndrome with cerebral hemorrhage that may be associated with fat-soluble vitamin deficiency

Wataru Shiraishi, M.D.1), Hayato Une, M.D.1)2), Yasutaka Iwanaga, M.D.1) and Akifumi Yamamoto, M.D.1)

1)Department of Neurology, Kyushu Kosei Nenkin Hospital
2)Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University

A 36-year-old woman with a 4 year history of lower legs edema, hypermenorrhea and melena without medical treatment was admitted to our hospital. At 18 days before admission, anasarca and general fatigue appeared and she was admitted to another hospital. Her hemoglobin concentration was 1.4 g/dl and chest X-ray showed cardiomegaly. Heart failure with severe chronic anemia was diagnosed, and blood transfusion was performed. Her hemoglobin concentration increased to 10 g/dl and the anasarca disappeared. The day after discharge, she was referred to our hospital with generalized convulsion. We diagnosed posterior reversible encephalopathy syndrome (PRES) from the typical MRI imaging. We started treatment and her consciousness recovered steadily. At a week after admission, left hemiparesis appeared. Her brain imaging revealed multiple intracranial hemorrhages. In addition, her visual disturbance revealed vitamin A and vitamin K deficiency. PRES sometimes occur secondary to blood transfusion, but secondary brain hemorrhage is rare. Her fat-soluble vitamin deficiency, which resulted from a peculiar eating habit, may have contributed to the brain hemorrhage.
Full Text of this Article in Japanese PDF (3168K)

(CLINICA NEUROL, 54: 518－521, 2014)
key words: posterior reversible encephalopathy syndrome, blood transfusion, brain hemorrhage, vitamin deficiency, visual disturbance

(Received: 25-Sep-13)