Rinsho Shinkeigaku (Clinical Neurology)

Symposium 34

Proton magnetic resonance spectroscopy as a time clock measurement device in cerebral ischemia

Hironaka Igarashi, M.D., Ph.D.

Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata

Proton magnetic resonance spectroscopy (1H-MRS) non-invasively provides in vivo biochemical information on tissue metabolites. In acute stage of cerebral ischemia, N-acetyl aspartate (NAA), one of 1H-MRS observable metabolite, declines gradually reflecting energy impairment due to oxygen depletion. In our study, decline of NAA in ischemic core linearly correlated with the time from the onset of ischemia. Therefore NAA can be utilized to time clock biomarker for the acute stage cerebral ischemia.
Full Text of this Article in Japanese PDF (342K)

(CLINICA NEUROL, 51: 1178|1181, 2011)
key words: brain ischemia, Magnetic Resonance Spectroscopy

(Received: 20-May-11)