Rinsho Shinkeigaku (Clinical Neurology)

The 51st Annual Meeting of the Japanese Society of Neurology

Japanese consortium for amyotrophic lateral sclerosis researchiJaCALSj

Naoki Atsuta, M.D.1) and Gen Sobue, M.D.2)

1)Department of Neurology, Nagoya University Hospital
2)Department of Neurology, Nagoya University Graduate School of Medicine

To investigate the longitudinal course of Japanese patients with Amyotrophic Lateral Sclerosis (ALS), we constructed a multicenter registration and follow-up system called Japanese Consortium for Amyotrophic Lateral Sclerosis research (JaCALS). Genomic DNA samples of ALS patients were stored and linked to the clinical information. We designed a telephone survey system using a clinical research coordinator (CRC) to check the score of the ALS Functional Rating Scale-R (ALSFRS-R) and the prognosis every 3 months. In January 2006, we began registering ALS patients, and, at present, 19 neurology facilities are participating in the JaCALS. Currently, 421 Japanese ALS patients are registered. The longitudinal courses and prognoses of 93% of the 284 patients over a year from registration have been recorded in this system. In collaboration with the RIKEN Center for Genomic Medicine, genome-wide association studies (GWAS) for ALS susceptibility genes were conducted using 981 ALS samples from the JaCALS and BioBank Japan. Novel associated genes were identified, and replication studies are underway. JaCALS has established an efficient registration and follow-up system with genomic DNA resources of ALS patients, and will contribute to identify ALS-associated genes and to promote clinical researches.
Full Text of this Article in Japanese PDF (255K)

(CLINICA NEUROL, 50: 928|930, 2010)
key words: Amyotrophic lateral sclerosis (ALS), natural history, genomic gene, prognostic factor, telephone survey

(Received: 22-May-10)