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- Vol.47 No.11
- CLINICA NEUROL, 47: 845|847, 2007
- Vol.47 No.11 contents
The 48th Annual Meeting of the Japanese Society of Neurology
A spectrum of neurological diseases with anti-VGKC antibody
Kimiyoshi Arimura, M.D., Osamu Watanabe, M.D. and Tatsui Nagado, M.D.
Department of Neurology and Geriatrics, Kagoshima University Graduate School of Medical and Dental Sciences
Anti-VGKC antibody causing peripheral nerve hyperexcitability is already an established clinical entity. Recently, many patients with non-herpetic limbic encephalitis (NHLE) with anti-VGKC antibody have been reported. The characteristic clinical features are low serum Na+ concentration and good response to immunotherapy. Anti-VGK antibody positive NHLE is relatively frequent among immune-mediated NHLE. It is important to know that this disease is responsive to immunotherapy. Furthermore, anti-VGKC antibody is also positive in some intractable epilepsies. These findings suggest that anti-VGKC is correlated with hyperexcitability in both the peripheral and central nervous system and that the spectrum of anti-VGKC antibody syndrome is now expanding.
(CLINICA NEUROL, 47: 845|847, 2007)
key words: limbic encephalitis, voltage-gated potassium channel, antibody, immunotherapy
(Received: 16-May-07)