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• Vol.45 No.9
• CLINICA NEUROL, 45: 669−673, 2005
• Vol.45 No.9 contents

Case Report

A patient with coccidioidal meningoencephalitis

Miho Nakata, M.D., Shoichi Ito, M.D., Yuriko Kikkawa, M.D. and Kaoru Katayama, M.D.

Department of Neurology, Narita Red Cross Hospital

A 37-year-old man presented with coccidioidal meningoencephalitis (CM) 1 month after a preceding case of pneumonia. Initially, he could not be definitely diagnosed with CM because of nonspecific features of the clinical, laboratory, and radiological findings. However, we began to suspect CM because the patient had lived in endemic area of coccidioidomycosis, and our subsequent analysis provided evidence of complement-fixing antibodies for Coccidioides immitis in serum and CSF, leading us to a final diagnosis. The CM was intractable, despite intensive administration of fluconazole and amphotericin B. Although the patient's CM gradually and mildly improved, he also suffered from bacterial meningoencephalitis and left putaminal hemorrhage with intraventricular hematoma, which caused persistent right hemiparesis and dementia.
The incidence of coccidioidomycosis in Japan is rapidly increasing. The initial clinical manifestation of coccidioidomycosis is usually pneumonia, which in most cases heals spontaneously. Coccidioidomycosis rarely presents with meningoencephalitis, which is thought to be fatal. Immediate and adequate initiation of anti-fugal treatment is necessary to obtain a better prognosis for CM. Careful history-taking after a foreign trip is helpful when there is a suspicion of coccidioidomycosis.

(CLINICA NEUROL, 45: 669−673, 2005)
key words: coccidioidomycosis, meningoencephalitis, Coccidioides immitis

(Received: 27-Jan-05)